Purpose of the development: Antitumor glycopeptide (SAW) is designed to create an immune response aimed at curbing the development of the tumor and prevent recurrence and metastasis.

Recommended application field: Medicine.

The development stage readiness: Introduced in production

Description of the development:
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General characteristics. Antitumor glycopeptide (SAW ) - The first domestic antineoplastic agent which is prepared from the patient's own tumor tissue and products of microbial synthesis ( lectins ) Bacillus subtilis B- 7025 . The purpose of using the surfactant is an individual patient prolonged induction of the immune response , aimed at curbing the development of tumors and prevent recurrence and metastazov.PAV is a yellowish liquid , which combines a modified tumor- associated antigens and cytotoxic lectins . Depending on the histogenesis of tumor tissue and consists of several antigens with molecular weights from 15 to 70 kD . It is harmless , non-toxic , sterile , has no anaphylactic properties , for its production are not used preservatives . SAW standardized by protein (using Lowry), his total on the course of vaccination is 45-60 mg Methods for producing cytotoxic lectins , surfactants and treatment of cancer patients are protected by 15 patents of Ukraine. State Service of drugs and medical supplies the Ministry of Health recognized that surfactant corresponds to domestic and international safety standards and allowed for widespread clinical use in Ukraine (Certificate № 411/03-300200000 9 December 2003) . The mechanism of action . Antitumor and antimetastatic efficacy of surfactant based on the activation of effector cell specific and nonspecific antitumor responses antigenprezentuyuschih cell activation , cytokine content etc. Immunization of surfactant leads to a statistically significant increase in T -and B - lymphocytes activated (p < 0.05 ) compared with the number before surgery . Marked increase in the relative content of CD3 and CD4 lymphocyte subpopulations simultaneously with the reduction of CD8, increased activity antigenprezentuyuschih cells. Immunization of surfactant leads to a considerable increase in production ? Interferon- ( 1.5-fold ) , interleukins 1 and 2 , tumor necrosis factor , serum cytotoxicity .

corresponds technical description
Ready for implementation

Possibility of transfer abroad:
Licence's sale
Licence's sale
Combinated reduction to industrial level
Creation of joint enterprise
Realization of finished commodity

Photo

Country Ukraine

For additional information turn to:
E-mail: gal@uintei.kiev.ua