Purpose of the development: Designed to enhance immunity. Used in the treatment of chronic sepsis and septic processes, burns, frostbite, conjunctivitis, corneal erosion, aphthous stomatitis and other infectious diseases. The drug is non-toxic, non-irritating to the tissues and can be used in poor tolerability other antibacterial drugs. Applied locally, sometimes intramuscularly.

Recommended application field: Medicine, food, cheese-making, dietary, medical and daily food. Manufacture of wines. Cosmetology. Veterinary Medicine.

The development stage readiness: Introduced in production

Description of the development:
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The preparation consists of a peptidoglycan-N-atsetilmuramilgidrolaza; Peptidoglycan-glyukopeptid-glyukogidrolaza; Muramidase. The enzyme with a molecular weight of about 15,000, composed of 129 amino acid residues. The enzyme catalyzes the hydrolysis reaction of 1,4-B-linkages between N-acetylmuramic acid and 2-atsetomido-2-deoxy-D-glucose (N-acetylglucosamine) contained in mucopolysaccharides and chitin mukopetidah cell walls of bacteria, fungi, protozoa. Has a pronounced anti-microbial (destroys the cell walls of most gram-positive and some gram-negative bacteria), mikostaticheskim (retards the development of microscopic fungi), and wound-healing effect. In nature, found in different organs and tissues of human and animal saliva and tears, which mainly performs the function of a barrier protection against microbial infection. It is widely distributed and its presence is considered one of the oldest and most important factors in immunity. The drug is harmless; LD50 with gastric administration> 5 g / kg, which can be attributed to its hazard class IV according to GOST 12.01.007-76; does not have the general toxic, skin-irritating and cytotoxic effect. Litsozim refers to elements ftsnktsionalnogo power and allowed the WHO Expert Committee on Food Additives for food fortification. In 1996 litsozim included in the list of food additives permitted in Russia for use in foodstuffs (SanPin 2.3.2.506.96). Food, obagaschёnnye litsezimom designed primarily for rehabilitation of children and adults, prevention and treatment of diseases of the gastrointestinal tract and immunodeficiency states of the human body. Practice more than 15 years of use litsozima in countries such as France, Italy, Germany, Spain, Denmark, Holland, Portugal and the United States have shown its high efficiency associated with improved organoleptic characteristics kachchestva and manufactured using them cheeses. Litsozim egg protein effectively destroys vegetative forms of bacteria Clostridium butyricum and Clostridium tyrobutyricum. The spores of these bacteria are able to withstand conventional heat treatment of milk prior to use it for the production of cheese and thereafter germinate directly by wet weight. The development of these bacteria in the cheese ripening period causes gas formation causing effect "peaking cheeses I" and formed during fermentation, butyric acid and isobutyric impart a bitter taste and odor worsen the finished product. Litsozim egg protein destroys the cell walls of bacteria and thus effectively restrain their development. Milk and milk podukty, as close as possible to the biological properties of human milk. When producing natural wines litsozim pressure used in Step grape wine material after processing SO2, immediately after mixing the wine for fermentation and slow to stabilize wine after lactic acid fermentation. The main purpose of litsozima - Controlling growth gramopolozhitelnyh bacteria such as Oenococcus oeni, Pediococcus and Lactobacillus. Lazotsim most active at neutral pH environment, which are most suitable for the development of lactic acid bacteria. In medical cosmetology and cosmetic industries lysozyme can be used as an active ingredient intended for breeding in the formulation of finished cosmetic products intended for skin care, body, scalp and nails to combat pathogens Bacterial infections and accelerate recovery processes operating in skin. Trials of the drug in the laboratory center Beauty Institute Health Ministry showed that the drug is biologically active and stimulates protein metabolism in the skin. A study of the use of drugs based on litsozima egg protein in meat and poultry industry, showed that litsozim containing drugs have proven as effective stimulants of humoral immunity. In 1991, the Latvian scientists conducted numerous scientific and industrial experiments with calves, pigs, sheep, broiler chickens, hens, ducks, turkeys and fur animals.

Information about newness of the development:
there are patents of other countries -- 9 items

Possibility of transfer abroad:
Licence's sale

Photo

Country Ukraine

For additional information turn to:
E-mail: gal@uintei.kiev.ua